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| CAS: | 976-71-6 | MF: | C22H28O3 |
|---|---|---|---|
| MW: | 340.46 | EINECS: | 213-554-5 |
| Purity: | 99%min. | Properties: | Powder |
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High Purity Glucocorticoid Steroids Canrenone CAS 976-71-6 for Antiinflammatory
Canrenone
Product Name: Canrenone
Synonyms: PREGNA-4,6-DIENE-17-BETA-0L-3-ONE-21-CARBOXYLIC ACID-GAMMA LACTONE;11614r.p;17-(2-Carboxyethyl)17-hydroxy-3-oxoandrosta-4,6-dienelactone;17-(2-Carboxyethyl)17-hydroxyandrosta-4,6-dien-3-onelactone;17-hydroxy-3-oxo-,gamma-lactone,(17-alpha)-pregna-6-diene-21-carboxylicacid;17-Hydroxy-3-oxo-17-pregna-4,6-diene-21-carboxylicacid-lactone;phanurane;pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph
CAS: 976-71-6
MF: C22H28O3
MW: 340.46
EINECS: 213-554-5
Chemical Properties Pale yellow to pale Green Solid
Usage Aldosterone antagonist. Diuretic
Usage antiinflammatory, glucocorticoid
Biological Activity Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ). Buy Canrenone (Cas 976-71-6) powder
Canrenone Description
The properties of the aldosterone antagonists spironolactone and potassium canrenoate in tablet formulations were examined in two studies in healthy subjects, the first study comparing levels of their common major metabolite, canrenone, in plasma and the second study comparing the pharmacological activity of the two drugs in reversing the renal effects of the synthetic mineralocorticoid fludrocortisone.
At equal dosage by weight potassium canrenoate yielded peak levels and areas under the curve for canrenone in plasma which were significantly lower than those for spironolactone, and the peak level of canrenone was reached significantly later. Comparison with published work suggests that the experimental formulation of potassium canrenoate had low bioavailability. Buy Canrenone (Cas 976-71-6) powder
Spironolactone produced statistically valid log dose-response curves against fludrocortisone as regards sodium excretion, potassium retention and increased urine sodium to potassium ratio. There was no significant log dose-reponse after potassium canrenoate, and a statistically valid estimate of relative potency could not be obtained. Buy Canrenone (Cas 976-71-6) powder
The results of the two studies seem inconsistent with the view that canrenone alone is responsible for the pharmacological activity of both drugs, and suggest that a significant part of the activity of spironolactone may be attributable to metabolites other than canrenone. Buy Canrenone (Cas 976-71-6) powder
Canrenone Applications:
Canrenone (Contaren, Luvion) is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe.
It is a major active metabolite of spironolactone, and is believed to be partially responsible for its effects.
Canrenone Specifications: Buy Canrenone (Cas 976-71-6) powder
| TEST ITEMS | SPECIFICATION | RESULTS |
| Description | : White or Almost White Crystalline Powder | white powder |
| Identification | : A.B. | Positive |
| Assay | : 97.0~103.0% | 99.3% |
| Specific Rotation | : +101°~+105° | +102.6° |
| Loss On Drying | : 1.0%max | 0.27% |
| Melting Point | : 153~157°C | 153.0~155.0°C |
| Organic Volatile Impurities | : meets the requirement. | Conforms |
| Related Substances | : meets the requirement. | Conforms |
| Residual Solvents | : meets the requirement. | Conforms |
| Particle Size | : 100% ≤ 20 microns | Conforms |
| Conclusion | The specification conform with USP30 standard | |
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